Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RB1 | P06400 | 10/20 | 0.49 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8793905 | 0.98 | RB1 (0.50) | RB1NR2E1SIGMAR1DRD2DRD1 | |
| SCHEMBL8822945 | 0.74 | RB1 (0.45) | RB1SIGMAR1DRD2DRD1 | |
| SCHEMBL24727249 | 0.73 | SIGMAR1 (0.49) | RB1NR2E1SIGMAR1DRD2DRD1 | |
| SCHEMBL8822941 | 0.71 | SMN1; SMN2 (0.46) | RB1SIGMAR1DRD2DRD1 | |
| SCHEMBL14473893 | 0.68 | BRD3 (0.58) | RB1NR2E1SIGMAR1DRD2DRD1 | |
| SCHEMBL8582769 | 0.68 | SIGMAR1 (0.47) | RB1NR2E1SIGMAR1DRD2DRD1 | |
| SCHEMBL28912217 | 0.68 | NR2E1 (0.50) | RB1NR2E1SIGMAR1DRD2DRD1 | |
| SCHEMBL28183138 | 0.68 | NR2E1 (0.46) | RB1NR2E1SIGMAR1DRD2DRD1 | |
| SCHEMBL8153656 | 0.68 | DRD2 (0.44) | NR2E1SIGMAR1DRD2DRD1 | |
| SCHEMBL8141916 | 0.68 | DRD2 (0.44) | NR2E1SIGMAR1DRD2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0496314-B1 | Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[b]indoles and related compounds, intermediates and a process for the preparation thereof and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1997-10-01 | — | — | EP | disclosed |
| US-5472975-A | Cognition activators, antidepressants | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1995-12-05 | — | — | US | disclosed |
| US-5192789-A | Antidepressants | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-03-09 | — | — | US | disclosed |
| EP-0496314-A1 | Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[b]indoles and related compounds, intermediates and a process for the preparation thereof and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-07-29 | — | — | EP | disclosed |
| US-5100891-A | Antidepressants | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1992-03-31 | — | — | US | disclosed |