Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | GBA1 | P04062 | 2/20 | 0.45 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171853 | 0.84 | SIGMAR1 (0.45) | S1PR5S1PR1GBA1ALDH1A1SIGMAR1 | |
| SCHEMBL844750 | 0.84 | SIGMAR1 (0.45) | S1PR5S1PR1GBA1ALDH1A1SIGMAR1 | |
| SCHEMBL844751 | 0.84 | SIGMAR1 (0.45) | S1PR5S1PR1GBA1ALDH1A1SIGMAR1 | |
| SCHEMBL844752 | 0.84 | SIGMAR1 (0.45) | S1PR5S1PR1GBA1ALDH1A1SIGMAR1 | |
| SCHEMBL7920949 | 0.84 | S1PR5 (0.57) | S1PR5S1PR1GBA1FUCA1TBXA2R | |
| SCHEMBL7920948 | 0.84 | S1PR5 (0.57) | S1PR5S1PR1GBA1FUCA1TBXA2R | |
| SCHEMBL7920954 | 0.84 | S1PR5 (0.57) | S1PR5S1PR1GBA1FUCA1TBXA2R | |
| SCHEMBL6491881 | 0.79 | SCN4A (0.46) | S1PR5KDM4ESIGMAR1 | |
| SCHEMBL8266080 | 0.77 | ACHE (0.45) | S1PR5S1PR1FUCA1KDM4EALDH1A1 | |
| SCHEMBL1202294 | 0.76 | CCR5 (0.48) | S1PR5S1PR1FUCA1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432707-B1 | AZABICYCLIC-SUBSTITUTED FUSED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN CO LLC (US) | 2012-03-28 | — | — | EP | disclosed |