Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31025898 | 0.87 | MTNR1A (0.50) | MTNR1AMTNR1BKDM4EGAANPSR1 | |
| SCHEMBL8794436 | 0.84 | L3MBTL1 (0.58) | MTNR1AMTNR1BKDM4EGAANPSR1 | |
| SCHEMBL8795026 | 0.81 | MTNR1A (0.48) | MTNR1AMTNR1BKDM4EGAANPSR1 | |
| SCHEMBL9671391 | 0.78 | MTNR1A (0.45) | MTNR1AMTNR1BKDM4EGAANPSR1 | |
| SCHEMBL11802166 | 0.77 | MTNR1A (0.55) | MTNR1AMTNR1BKDM4EGAANPSR1 | |
| SCHEMBL14492311 | 0.75 | KDM4E (0.58) | MTNR1AMTNR1BKDM4EGAAMAPT | |
| SCHEMBL17417787 | 0.73 | PRKAG1 (0.66) | MTNR1AMTNR1BMEN1KMT2ALMNA | |
| SCHEMBL19322240 | 0.71 | MTNR1A (0.42) | MTNR1AMTNR1BKDM4EGAANPSR1 | |
| SCHEMBL4344125 | 0.71 | KDM4E (0.71) | KDM4EGAANPSR1MAPTTDP1 | |
| SCHEMBL27948924 | 0.71 | GPR35 (0.66) | MAPTCYP1A2CYP2C9GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652239-A | TREATMENT OF STROKES, ISCHEMIC ATTACK, ANTAGONISTS OF EXCITATORY AMINO ACIDS GLUTAMATE AND ASPARTATE | IMPERIAL CHEMICAL COMPANY (GB) | 1997-07-29 | — | — | US | disclosed |
| EP-0512817-B1 | Pyridazinedione derivatives, their preparation and pharmaceutical applications | ZENECA LTD (GB) | 1997-02-19 | — | — | EP | disclosed |
| EP-0512817-A1 | Pyridazinedione derivatives, their preparation and pharmaceutical applications | ZENECA LIMITED (GB) | 1992-11-11 | — | — | EP | disclosed |