Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24372709 | 0.84 | L3MBTL1 (0.37) | RAB9AALDH1A1LMNAHTTNPC1 | |
| SCHEMBL1765588 | 0.84 | ALDH1A1 (0.39) | RAB9AALDH1A1LMNAHTTNPC1 | |
| SCHEMBL8763816 | 0.84 | TSHR (0.42) | RAB9AALDH1A1LMNAHTTNPC1 | |
| SCHEMBL4931670 | 0.80 | RAB9A (0.35) | RAB9AALDH1A1LMNAHTTNPC1 | |
| SCHEMBL396571 | 0.77 | RAB9A (0.42) | RAB9AALDH1A1LMNAHTTNPC1 | |
| SCHEMBL386837 | 0.77 | ALDH1A1 (0.48) | RAB9AALDH1A1LMNAHTTMAPT | |
| SCHEMBL25773118 | 0.75 | L3MBTL1 (0.33) | RAB9AALDH1A1LMNAHTTNPC1 | |
| SCHEMBL2653825 | 0.72 | L3MBTL1 (0.44) | RAB9AALDH1A1LMNAHTTNPC1 | |
| SCHEMBL9265658 | 0.72 | L3MBTL1 (0.47) | RAB9ANPSR1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL13858439 | 0.72 | CYP4F2 (0.42) | RAB9AALDH1A1LMNAHTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760811-A1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H 3? (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1997-03-12 | — | — | EP | claimed |
| EP-0552553-B1 | Sulfonimidamides as antineoplastic agents | LILLY CO ELI (US) | 1997-07-23 | — | — | EP | disclosed |
| US-5258406-A | Antitumor agents | ELI LILLY AND COMPANY (US) | 1993-11-02 | — | — | US | disclosed |
| EP-0552553-A1 | Sulfonimidamides as antineoplastic agents | ELI LILLY AND COMPANY (US) | 1993-07-28 | — | — | EP | disclosed |