Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 5/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9182766 | 0.73 | CMKLR1 (0.50) | CRHR1 | |
| SCHEMBL8683090 | 0.73 | CRHR1 (0.38) | CRHR1KMT2ADPP4 | |
| SCHEMBL8793483 | 0.72 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL8683102 | 0.72 | CRHR1 (0.40) | CRHR1KMT2ADPP4 | |
| SCHEMBL8839004 | 0.71 | CRHR1 (0.39) | CRHR1CNR1KMT2ADHODH | |
| SCHEMBL8682531 | 0.71 | CRHR1 (0.37) | CRHR1MAPTKMT2A | |
| SCHEMBL8681643 | 0.71 | CRHR1 (0.37) | CRHR1KMT2A | |
| SCHEMBL22293254 | 0.71 | G6PC1 (0.39) | KMT2A | |
| SCHEMBL8682538 | 0.71 | CRHR1 (0.39) | CRHR1KMT2A | |
| SCHEMBL8681648 | 0.71 | CRHR1 (0.39) | CRHR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0576350-B1 | Branched alkylamino thiazole derivatives, process for their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1997-10-29 | — | — | EP | disclosed |
| EP-0576350-A1 | Branched alkylamino thiozole derivatives, process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1993-12-29 | — | — | EP | disclosed |