Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9435245 | 0.88 | KMT2A (0.34) | KDM4EKMT2AMAPK1MEN1BACE1 | |
| SCHEMBL8773869 | 0.73 | POLB (0.41) | KDM4EKMT2AMAPK1MEN1BACE1 | |
| SCHEMBL9031190 | 0.73 | ALDH1A1 (0.49) | KDM4EKMT2AMAPK1MEN1HSD17B10 | |
| SCHEMBL239767 | 0.71 | KMT2A (0.53) | KDM4EKMT2AMEN1HSD17B10SMN1; SMN2 | |
| SCHEMBL7264596 | 0.71 | KMT2A (0.54) | KMT2AMEN1HSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL2192678 | 0.71 | HSD17B10 (0.42) | KDM4EKMT2AMAPK1MEN1HSD17B10 | |
| SCHEMBL8794840 | 0.71 | LMNA (0.54) | KDM4EKMT2AMEN1BACE1HSD17B10 | |
| SCHEMBL5478604 | 0.70 | ALDH1A1 (0.38) | HSD17B10ALDH1A1 | |
| SCHEMBL28269576 | 0.70 | ALDH1A1 (0.51) | MAPK1HSD17B10SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL7810225 | 0.70 | CA1 (0.45) | KDM4EKMT2AMEN1BACE1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0611003-B1 | Substituted phenyl sulfonamides as selective B3 agonists for the treatment of diabetes and obesity | MERCK & CO INC (US) | 1997-06-18 | — | — | EP | disclosed |
| US-5451677-A | Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity | MERCK & CO., INC. (US) | 1995-09-19 | — | — | US | disclosed |
| WO-1994018161-A1 | SUBSTITUTED PHENYL SULFONAMIDES AS SELECTIVE β3 AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY | MERCK & CO., INC. (US) | 1994-08-18 | — | — | WO | disclosed |
| EP-0611003-A1 | Substituted phenyl sulfonamides as selective B3 agonists for the treatment of diabetes and obesity | MERCK & CO. INC. (US) | 1994-08-17 | — | — | EP | disclosed |