SCHEMBL8795126

SCHEMBL8795126

CC(C)Nc1cccnc1N1CCN(C(=O)c2c[nH]c3cc([N+](=O)[O-])ccc23)CC1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA2A P08913 1/20 0.48
ADORA3 P0DMS8 1/20 0.48
CHRM1 P11229 1/20 0.48
MAOA P21397 1/20 0.48
TBXA2R P21731 1/20 0.48
OPRM1 P35372 1/20 0.48
MDH1 P40925 1/20 0.48
KCNH2 Q12809 1/20 0.48
ABCG2 Q9UNQ0 1/20 0.48
TNFSF11 O14788 2/20 0.47
TNF P01375 2/20 0.47
SLC6A9 P48067 1/20 0.46
SLC6A5 Q9Y345 1/20 0.46
KMT2A Q03164 1/20 0.43
AVPR1A P37288 2/20 0.41
HTT P42858 1/20 0.41
ALDH1A1 P00352 2/20 0.41
KDM1A O60341 1/20 0.41
TRPV1 Q8NER1 1/20 0.40
GFER P55789 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8795151 0.93 TNFSF11 (0.56) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9037304 0.86 ADRA2A (0.51) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9037017 0.85 ADRA2A (0.50) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9037801 0.85 GFER (0.55) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9036880 0.85 ADRA2A (0.49) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9038099 0.85 ADRA2A (0.49) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9038780 0.85 ADRA2A (0.49) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9038924 0.85 ADRA2A (0.49) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9035802 0.84 ADRA2A (0.49) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9037405 0.83 ADRA2A (0.48) ADRA2AADORA3CHRM1MAOATBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0507861-B1 DIAROMATIC SUBSTITUTED ANTI-AIDS COMPOUNDS UPJOHN CO (US) 1996-09-11 EP claimed
US-5599930-A Substituted indoles as anti-AIDS pharmaceuticals THE UPJOHN COMPANY (US) 1997-02-04 US disclosed
EP-0594702-B1 SUBSTITUTED INDOLES AS ANTI-AIDS PHARMACEUTICALS UPJOHN CO (US) 1997-01-29 EP disclosed
WO-1993001181-A1 SUBSTITUTED INDOLES AS ANTI-AIDS PHARMACEUTICALS THE UPJOHN COMPANY (US) 1993-01-21 WO disclosed