SCHEMBL9036880

SCHEMBL9036880

CC(C)Nc1cccnc1N1CCN(C(=O)c2c[nH]c3cc(N(C)C)ccc23)CC1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA2A P08913 1/20 0.49
ADORA3 P0DMS8 1/20 0.49
CHRM1 P11229 1/20 0.49
MAOA P21397 1/20 0.49
TBXA2R P21731 1/20 0.49
OPRM1 P35372 1/20 0.49
MDH1 P40925 1/20 0.49
KCNH2 Q12809 1/20 0.49
ABCG2 Q9UNQ0 1/20 0.49
AVPR1A P37288 5/20 0.42
GFER P55789 1/20 0.40
IDH1 O75874 1/20 0.38
KIT P10721 1/20 0.36
CLEC4M Q9H2X3 1/20 0.35
MEN1 O00255 1/20 0.35
ALDH1A1 P00352 1/20 0.35
TP53 P04637 1/20 0.35
CYP3A4 P08684 1/20 0.35
GAA P10253 1/20 0.35
CYP2D6 P10635 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9037247 0.89 AVPR1A (0.43) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9037304 0.88 ADRA2A (0.51) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9037405 0.87 ADRA2A (0.48) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9037017 0.87 ADRA2A (0.50) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9037801 0.86 GFER (0.55) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9038780 0.86 ADRA2A (0.49) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9038924 0.86 ADRA2A (0.49) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9038099 0.86 ADRA2A (0.49) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9035802 0.85 ADRA2A (0.49) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL8795126 0.85 ADRA2A (0.48) ADRA2AADORA3CHRM1MAOATBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0507861-B1 DIAROMATIC SUBSTITUTED ANTI-AIDS COMPOUNDS UPJOHN CO (US) 1996-09-11 EP claimed
WO-1991009849-A1 DIAROMATIC SUBSTITUTED ANTI-AIDS COMPOUNDS THE UPJOHN COMPANY (US) 1991-07-11 WO claimed