SCHEMBL9038780

SCHEMBL9038780

COc1ccc2c(C(=O)N3CCN(c4ncccc4NC(C)C)CC3)c[nH]c2c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA2A P08913 1/20 0.49
ADORA3 P0DMS8 1/20 0.49
CHRM1 P11229 1/20 0.49
MAOA P21397 1/20 0.49
TBXA2R P21731 1/20 0.49
OPRM1 P35372 1/20 0.49
MDH1 P40925 1/20 0.49
KCNH2 Q12809 1/20 0.49
ABCG2 Q9UNQ0 1/20 0.49
MAPT P10636 4/20 0.45
MEN1 O00255 2/20 0.45
KMT2A Q03164 2/20 0.45
DRD2 P14416 1/20 0.45
DRD3 P35462 1/20 0.45
RECQL P46063 1/20 0.45
ALDH1A1 P00352 4/20 0.45
KDM4E B2RXH2 4/20 0.45
HPGD P15428 2/20 0.45
HSD17B10 Q99714 1/20 0.45
KDR P35968 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8985918 0.93 ALDH1A1 (0.52) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9037435 0.89 ADRA2A (0.50) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL8793292 0.88 ADRA2A (0.45) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL8794858 0.88 ADRA2A (0.45) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9037304 0.88 ADRA2A (0.51) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9037017 0.87 ADRA2A (0.50) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9037801 0.86 GFER (0.55) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9038099 0.86 ADRA2A (0.49) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9036880 0.86 ADRA2A (0.49) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9038924 0.86 ADRA2A (0.49) ADRA2AADORA3CHRM1MAOATBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0507861-B1 DIAROMATIC SUBSTITUTED ANTI-AIDS COMPOUNDS UPJOHN CO (US) 1996-09-11 EP claimed
WO-1991009849-A1 DIAROMATIC SUBSTITUTED ANTI-AIDS COMPOUNDS THE UPJOHN COMPANY (US) 1991-07-11 WO claimed