Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 7/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 6/20 | 0.44 |
| ▸ | GSK3A | P49840 | 6/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 5/20 | 0.44 |
| ▸ | CDK1 | P06493 | 5/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 5/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.38 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 4/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | STK17B | O94768 | 1/20 | 0.32 |
| ▸ | TYMS | P04818 | 2/20 | 0.31 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8793829 | 0.80 | GSK3B (0.48) | GSK3BCDK5CDK5R1GSK3ACCNB2 | |
| SCHEMBL8794489 | 0.80 | PARP1 (0.49) | GSK3BCDK5CDK5R1GSK3ACCNB2 | |
| SCHEMBL7412080 | 0.77 | ALDH1A1 (0.48) | GSK3BCDK5CDK5R1GSK3ACCNB2 | |
| SCHEMBL8794843 | 0.76 | KDM4E (0.53) | GSK3BCDK5CDK5R1CCNB2CDK1 | |
| SCHEMBL8793865 | 0.76 | KIF11 (0.51) | — | |
| SCHEMBL8794931 | 0.70 | KDM4E (0.48) | GSK3BGSK3AFLT3 | |
| SCHEMBL31167210 | 0.69 | AHR (0.44) | GSK3BCDK5CDK5R1GSK3ACCNB2 | |
| SCHEMBL6369969 | 0.69 | AHR (0.44) | GSK3BCDK5CDK5R1GSK3ACCNB2 | |
| SCHEMBL23876376 | 0.67 | PARP1 (0.62) | GSK3BCDK5CDK5R1GSK3ACCNB2 | |
| SCHEMBL6326783 | 0.67 | ALDH1A1 (0.55) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512817-B1 | Pyridazinedione derivatives, their preparation and pharmaceutical applications | ZENECA LTD (GB) | 1997-02-19 | — | — | EP | claimed |
| EP-0512817-A1 | Pyridazinedione derivatives, their preparation and pharmaceutical applications | ZENECA LIMITED (GB) | 1992-11-11 | — | — | EP | claimed |
| US-5652239-A | TREATMENT OF STROKES, ISCHEMIC ATTACK, ANTAGONISTS OF EXCITATORY AMINO ACIDS GLUTAMATE AND ASPARTATE | IMPERIAL CHEMICAL COMPANY (GB) | 1997-07-29 | — | — | US | disclosed |
| EP-0512817-B1 | Pyridazinedione derivatives, their preparation and pharmaceutical applications | ZENECA LTD (GB) | 1997-02-19 | — | — | EP | disclosed |
| EP-0512817-A1 | Pyridazinedione derivatives, their preparation and pharmaceutical applications | ZENECA LIMITED (GB) | 1992-11-11 | — | — | EP | disclosed |