Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.48 |
| ▸ | GSK3A | P49840 | 6/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.48 |
| ▸ | CDK1 | P06493 | 4/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.48 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.48 |
| ▸ | CDK4 | P11802 | 3/20 | 0.44 |
| ▸ | CCND1 | P24385 | 3/20 | 0.44 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.44 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.44 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.44 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.44 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8794489 | 0.80 | PARP1 (0.49) | GSK3BGSK3ACDK5CDK5R1CCNB2 | |
| SCHEMBL8795167 | 0.80 | GSK3B (0.44) | GSK3BGSK3ACDK5CDK5R1CCNB2 | |
| SCHEMBL7412080 | 0.77 | ALDH1A1 (0.48) | GSK3BGSK3ACDK5CDK5R1CCNB2 | |
| SCHEMBL8794843 | 0.76 | KDM4E (0.53) | GSK3BCDK5CDK5R1CCNB2CDK1 | |
| SCHEMBL8793865 | 0.76 | KIF11 (0.51) | CDK4CCND1MAPTNFKB1 | |
| SCHEMBL8794545 | 0.73 | GPR17 (0.35) | GSK3BGSK3ACDK5CDK5R1CCNB2 | |
| SCHEMBL8796099 | 0.71 | GRIN2D (0.50) | GSK3BCDK5CDK5R1CCNB2CDK1 | |
| SCHEMBL17867262 | 0.70 | GSK3B (0.46) | GSK3BGSK3ACDK5CDK5R1CCNB2 | |
| SCHEMBL8794931 | 0.70 | KDM4E (0.48) | GSK3BGSK3ACAMK2BCAMK2GCAMK2D | |
| SCHEMBL181890 | 0.69 | METAP2 (0.52) | GSK3BGSK3ACDK5CDK5R1CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512817-B1 | Pyridazinedione derivatives, their preparation and pharmaceutical applications | ZENECA LTD (GB) | 1997-02-19 | — | — | EP | claimed |
| EP-0512817-A1 | Pyridazinedione derivatives, their preparation and pharmaceutical applications | ZENECA LIMITED (GB) | 1992-11-11 | — | — | EP | claimed |
| US-5652239-A | TREATMENT OF STROKES, ISCHEMIC ATTACK, ANTAGONISTS OF EXCITATORY AMINO ACIDS GLUTAMATE AND ASPARTATE | IMPERIAL CHEMICAL COMPANY (GB) | 1997-07-29 | — | — | US | disclosed |
| EP-0512817-B1 | Pyridazinedione derivatives, their preparation and pharmaceutical applications | ZENECA LTD (GB) | 1997-02-19 | — | — | EP | disclosed |
| EP-0671378-B1 | Process for the preparation of (1R,4S)-4-hydroxy-1,2,2-trimethylcyclopentyl-methylketone, its derivatives and stereoisomers | BASF AG (DE) | 1997-01-29 | — | — | EP | disclosed |
| EP-0671378-A1 | Process for the preparation of (1R,4S)-4-hydroxy-1,2,2-trimethylcyclopentyl-methylketone, its derivatives and stereoisomers | BASF AKTIENGESELLSCHAFT (DE) | 1995-09-13 | — | — | EP | disclosed |
| EP-0512817-A1 | Pyridazinedione derivatives, their preparation and pharmaceutical applications | ZENECA LIMITED (GB) | 1992-11-11 | — | — | EP | disclosed |