Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8795499 | 1.00 | KMT2A (0.44) | KMT2AMEN1MAPTRAB9AALDH1A1 | |
| SCHEMBL8796260 | 0.83 | MAPT (0.45) | MAPTRAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL8796270 | 0.83 | MAPT (0.45) | MAPTRAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL8795690 | 0.83 | KMT2A (0.36) | KMT2AMEN1MAPTNPC1SMN1; SMN2 | |
| SCHEMBL8795697 | 0.83 | KMT2A (0.36) | KMT2AMEN1MAPTNPC1SMN1; SMN2 | |
| SCHEMBL8796246 | 0.83 | RARA (0.41) | MAPTRAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL8796237 | 0.83 | RARA (0.41) | MAPTRAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL8795809 | 0.81 | NPC1 (0.39) | MAPTRAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL8796886 | 0.81 | PLA2G4A (0.45) | MAPTRAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL8796891 | 0.81 | PLA2G4A (0.45) | MAPTRAB9AALDH1A1NPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629604-B1 | Alicyclic phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-04-16 | — | — | EP | disclosed |
| EP-0594702-B1 | SUBSTITUTED INDOLES AS ANTI-AIDS PHARMACEUTICALS | UPJOHN CO (US) | 1997-01-29 | — | — | EP | disclosed |
| US-5436369-A | Alicyclic phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0629604-A2 | Alicyclic phospholipase A2 inhibitors | Bristol-Myers Company (US) | 1994-12-21 | — | — | EP | disclosed |