Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NMT2 | O60551 | 3/20 | 0.38 |
| ▸ | NMT1 | P30419 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8795820 | 1.00 | NPC1 (0.39) | NPC1CYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL8796548 | 0.91 | SMPD1 (0.37) | CYP1A2CYP2C9HPGDCYP2C19SMN1; SMN2 | |
| SCHEMBL8796557 | 0.91 | SMPD1 (0.37) | CYP1A2CYP2C9HPGDCYP2C19SMN1; SMN2 | |
| SCHEMBL8796565 | 0.87 | PTPN11 (0.37) | HPGDSMN1; SMN2PTPN11PLA2G4ALTB4R | |
| SCHEMBL8796569 | 0.87 | PTPN11 (0.37) | HPGDSMN1; SMN2PTPN11PLA2G4ALTB4R | |
| SCHEMBL8796294 | 0.86 | PTPN11 (0.36) | HPGDSMN1; SMN2PTPN11PLA2G4ALTB4R | |
| SCHEMBL8796289 | 0.86 | PTPN11 (0.36) | HPGDSMN1; SMN2PTPN11PLA2G4ALTB4R | |
| SCHEMBL8796082 | 0.84 | NPC1 (0.43) | NPC1CYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL8796076 | 0.84 | NPC1 (0.43) | NPC1CYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL8797129 | 0.81 | PLA2G4A (0.48) | NPC1SMN1; SMN2MAPTPLA2G4ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629604-B1 | Alicyclic phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-04-16 | — | — | EP | disclosed |
| US-5436369-A | Alicyclic phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0629604-A2 | Alicyclic phospholipase A2 inhibitors | Bristol-Myers Company (US) | 1994-12-21 | — | — | EP | disclosed |