Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8795697 | 1.00 | KMT2A (0.36) | KMT2AMAPTPTGS2TP53BP1CCR6 | |
| SCHEMBL8795848 | 0.83 | PLA2G4A (0.46) | MAPTNPC1SMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL8795838 | 0.83 | PLA2G4A (0.46) | MAPTNPC1SMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL8795499 | 0.83 | KMT2A (0.44) | KMT2AMAPTMEN1CYP1A2KDM4E | |
| SCHEMBL8795222 | 0.83 | KMT2A (0.44) | KMT2AMAPTMEN1CYP1A2KDM4E | |
| SCHEMBL8796136 | 0.81 | NPC1 (0.39) | MAPTTP53BP1KDM4ENPC1SMN1; SMN2 | |
| SCHEMBL8796142 | 0.81 | NPC1 (0.39) | MAPTTP53BP1KDM4ENPC1SMN1; SMN2 | |
| SCHEMBL8796491 | 0.81 | RARG (0.38) | CYP1A2KDM4ENPC1CYP2C19CYP3A4 | |
| SCHEMBL8796493 | 0.81 | RARG (0.38) | CYP1A2KDM4ENPC1CYP2C19CYP3A4 | |
| SCHEMBL8796294 | 0.80 | PTPN11 (0.36) | KMT2AMEN1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629604-B1 | Alicyclic phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-04-16 | — | — | EP | disclosed |
| US-5436369-A | Alicyclic phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0629604-A2 | Alicyclic phospholipase A2 inhibitors | Bristol-Myers Company (US) | 1994-12-21 | — | — | EP | disclosed |