Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8796193 | 0.86 | CXCR3 (0.36) | SCN9ACXCR3TP53CYP1A2CYP3A4 | |
| SCHEMBL4614199 | 0.77 | SCN9A (0.35) | SCN9ASCN5AMEN1POLBGAA | |
| SCHEMBL8796050 | 0.75 | CYP3A4 (0.35) | SCN9ACXCR3TP53CYP1A2CYP3A4 | |
| SCHEMBL345589 | 0.73 | HTR2A (0.42) | SCN9ACYP3A4MEN1POLBGAA | |
| SCHEMBL16516779 | 0.71 | CYP3A4 (0.37) | CXCR3CYP3A4CYP2C19 | |
| SCHEMBL16046506 | 0.70 | CHRNB2 (0.38) | SCN9AMEN1POLBGAAKMT2A | |
| SCHEMBL2710155 | 0.69 | G6PD (0.36) | SCN9AMEN1GAAKMT2A | |
| SCHEMBL22321085 | 0.69 | MEN1 (0.41) | SCN9AMEN1POLBGAAKMT2A | |
| SCHEMBL4614491 | 0.69 | SCN9A (0.34) | SCN9AMEN1POLBGAAKMT2A | |
| SCHEMBL27199179 | 0.69 | SCN9A (0.34) | SCN9ATP53CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0664282-B1 | Biaryl phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-10-22 | — | — | EP | disclosed |
| EP-0629604-B1 | Alicyclic phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-04-16 | — | — | EP | disclosed |
| EP-0664282-A1 | Biaryl phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-26 | — | — | EP | disclosed |
| US-5436369-A | Alicyclic phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| CN-1099380-A | Alicyclic phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1995-03-01 | — | — | CN | disclosed |
| US-5391817-A | Antiinflammatory agents | BRISTOL-MYERS SQUIBB (US) | 1995-02-21 | — | — | US | disclosed |
| EP-0629604-A2 | Alicyclic phospholipase A2 inhibitors | Bristol-Myers Company (US) | 1994-12-21 | — | — | EP | disclosed |