⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31656490 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL29151203 | 0.97 | NUDT1 (0.46) | — | |
| Formic Acid SCHEMBL15056256 | 0.87 | GRM4 (0.41) | — | |
| SCHEMBL558033 | 0.84 | — | — | |
| Hydrochloric Acid SCHEMBL28160401 | 0.82 | NOS3 (0.46) | — | |
| Hydrochloric Acid SCHEMBL27632604 | 0.82 | NOS3 (0.46) | — | |
| Ammonia Solution, Strong SCHEMBL5132889 | 0.82 | NOS3 (0.46) | — | |
| SCHEMBL1586143 | 0.79 | — | — | |
| Ammonia Solution, Strong SCHEMBL28432870 | 0.77 | LMNA (0.48) | — | |
| SCHEMBL8164956 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 193 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220249475-A1 | COMPOUNDS AND METHOD FOR TREATING CYTOKINE RELEASE SYNDROME | RIGEL PHARMACEUTICALS, INC. (US) | 2022-08-11 | — | — | US | claimed |
| US-20220218705-A1 | COMPOUNDS AND METHOD FOR TREATING AUTOIMMUNE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2022-07-14 | — | — | US | claimed |
| CN-107619407-A | Double target spot inhibitor of HDAC and VEGFR based on pazopanib structure and its preparation method and application | 山东大学 | 2018-01-23 | — | — | CN | claimed |
| CN-105263923-B | Pyrimidine compounds and their use as gamma secretase modulators | 阿克图拉姆生命科学股份公司 | 2017-06-23 | — | — | CN | claimed |
| CN-105377852-A | Treatment of autoimmune disease | MINGSIGHT PHARMACEUTICALS INC | 2016-03-02 | — | — | CN | claimed |
| EP-2968331-A1 | PYRIMIDINE COMPOUNDS AS KINASE INHIBITORS | Icahn School of Medicine at Mount Sinai (US) | 2016-01-20 | — | — | EP | claimed |
| WO-2014151682-A1 | PYRIMIDINE COMPOUNDS AS KINASE INHIBITORS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2014-09-25 | — | — | WO | claimed |
| CN-103003264-B | Novel pyrimidine derivatives | CHEMILIA AB | 2014-08-06 | — | — | CN | claimed |
| CN-101646673-B | 3-amino-pyrrolo [3,4-C ] pyrazole-5 (1H,4H,6H) carbaldehyde derivatives as PKC inhibitors | PFIZER US | 2014-06-25 | — | — | CN | claimed |
| CN-103864764-A | Indazole-substituted pyrimidinamine derivative, and preparation method and use thereof | QILU PHARMACEUTICAL CO LTD | 2014-06-18 | — | — | CN | claimed |
| EP-2389372-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | Rigel Pharmaceuticals, Inc. (US) | 2011-11-30 | — | — | EP | claimed |
| WO-2011144742-A1 | NOVEL PYRIMIDINE DERIVATIVES | CHEMILIA AB (SE) | 2011-11-24 | — | — | WO | claimed |
| US-8039479-B2 | Such as 6-{5-Chloro-4-[2-(propane-2-sulfonyl)-phenylamino]-pyrimidin-2-ylamino}-5-isopropoxy-2-piperidin-4-yl-2,3-dihydro-isoindol-1-one; tumors, cancer; inhibition of anaplastic lymphoma, focal adhesion, zeta chain associated protein 70 and/or insulin like growth factor | IRM LLC (BM) | 2011-10-18 | — | — | US | claimed |
| US-8037782-B2 | Steering column assembly | FUJI KIKO CO., LTD. (JP) | 2011-10-18 | — | — | US | claimed |
| WO-2010085684-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2010-07-29 | — | — | WO | claimed |
| WO-2008118822-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2008-10-02 | — | — | WO | claimed |
| WO-2007009681-A1 | 1 , 1-DIOXID0-2 , 3-DIHYDRO-l , 2-BENZISOTHIAZ0L-6-YL-1H-INDAZOL-4-YL-2 , 4-PYRIMIDINEDI AMINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2007-01-25 | — | — | WO | claimed |
| EP-0714396-B1 | VASOCONTRICTIVE DIHYDROBENZOPYRAN DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-12-10 | — | — | EP | claimed |
| CN-1344266-A | Novel compounds | ASTRAZENECA AB (SE) | 2002-04-10 | — | — | CN | claimed |
| US-4116958-A | ORGANIC SYNTHETIC METHODS BENZYLPYRIMIDINE DERIVATIVES | BURROUGHS WELLCOME CO. (US) | 1978-09-26 | — | — | US | claimed |