Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.33 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.33 |
| ▸ | SMPD1 | P17405 | 4/20 | 0.33 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.32 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.32 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8796289 | 1.00 | PTPN11 (0.36) | PTPN11PLA2G4AEGFRSMN1; SMN2NPSR1 | |
| SCHEMBL8796565 | 0.99 | PTPN11 (0.37) | PTPN11PLA2G4AEGFRSMN1; SMN2NPSR1 | |
| SCHEMBL8796569 | 0.99 | PTPN11 (0.37) | PTPN11PLA2G4AEGFRSMN1; SMN2NPSR1 | |
| SCHEMBL8795838 | 0.87 | PLA2G4A (0.46) | PLA2G4ASMN1; SMN2POLBSMPD1 | |
| SCHEMBL8795848 | 0.87 | PLA2G4A (0.46) | PLA2G4ASMN1; SMN2POLBSMPD1 | |
| SCHEMBL8796557 | 0.87 | SMPD1 (0.37) | PTPN11PLA2G4ASMN1; SMN2HPGDPOLB | |
| SCHEMBL8796548 | 0.87 | SMPD1 (0.37) | PTPN11PLA2G4ASMN1; SMN2HPGDPOLB | |
| SCHEMBL8795820 | 0.86 | NPC1 (0.39) | PTPN11PLA2G4ASMN1; SMN2HPGDLTB4R | |
| SCHEMBL8795809 | 0.86 | NPC1 (0.39) | PTPN11PLA2G4ASMN1; SMN2HPGDLTB4R | |
| SCHEMBL8795586 | 0.82 | PTPN11 (0.41) | PTPN11PLA2G4AEGFRSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629604-B1 | Alicyclic phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-04-16 | — | — | EP | disclosed |
| US-5436369-A | Alicyclic phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-25 | — | — | US | disclosed |