Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 4/20 | 0.37 |
| ▸ | CNR2 | P34972 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MDH1 | P40925 | 2/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.35 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8796557 | 1.00 | SMPD1 (0.37) | SMPD1CNR2HPGDALDH1A1CYP1A2 | |
| SCHEMBL8795820 | 0.91 | NPC1 (0.39) | HPGDCYP1A2MAPTCYP2C9CYP2C19 | |
| SCHEMBL8795809 | 0.91 | NPC1 (0.39) | HPGDCYP1A2MAPTCYP2C9CYP2C19 | |
| SCHEMBL8797129 | 0.88 | PLA2G4A (0.48) | SMPD1MAPTSMN1; SMN2MDH1PLA2G4A | |
| SCHEMBL8797137 | 0.88 | PLA2G4A (0.48) | SMPD1MAPTSMN1; SMN2MDH1PLA2G4A | |
| SCHEMBL8796289 | 0.87 | PTPN11 (0.36) | SMPD1HPGDALDH1A1SMN1; SMN2PTPN11 | |
| SCHEMBL8796294 | 0.87 | PTPN11 (0.36) | SMPD1HPGDALDH1A1SMN1; SMN2PTPN11 | |
| SCHEMBL8796569 | 0.86 | PTPN11 (0.37) | SMPD1HPGDSMN1; SMN2PTPN11PLA2G4A | |
| SCHEMBL8796565 | 0.86 | PTPN11 (0.37) | SMPD1HPGDSMN1; SMN2PTPN11PLA2G4A | |
| SCHEMBL8795594 | 0.84 | SMPD1 (0.42) | SMPD1CNR2HPGDALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629604-B1 | Alicyclic phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-04-16 | — | — | EP | disclosed |
| US-5436369-A | Alicyclic phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-25 | — | — | US | disclosed |