Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 6/20 | 0.67 |
| ▸ | KDR | P35968 | 5/20 | 0.67 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.67 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.67 |
| ▸ | KIT | P10721 | 3/20 | 0.67 |
| ▸ | LCK | P06239 | 3/20 | 0.67 |
| ▸ | CSF1R | P07333 | 3/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.67 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.67 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.67 |
| ▸ | FLT3 | P36888 | 2/20 | 0.67 |
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.67 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.67 |
| ▸ | PLK4 | O00444 | 2/20 | 0.67 |
| ▸ | AURKA | O14965 | 2/20 | 0.67 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.67 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.67 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.67 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.67 |
| ▸ | CDK1 | P06493 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29693577 | 0.81 | ALDH1A1 (1.00) | TTKKDRMAPK8MAPK9KIT | |
| SCHEMBL29941507 | 0.81 | ALDH1A1 (1.00) | TTKKDRMAPK8MAPK9KIT | |
| SCHEMBL170980 | 0.81 | ALDH1A1 (1.00) | TTKKDRMAPK8MAPK9KIT | |
| SCHEMBL8866586 | 0.74 | TTK (0.73) | TTKKDRMAPK8MAPK9KIT | |
| SCHEMBL7817760 | 0.73 | PIM1 (0.72) | TTKKDRMAPK8MAPK9KIT | |
| SCHEMBL7830253 | 0.72 | MEN1 (0.52) | MAPK1KDM4ENPC1ALDH1A1MEN1 | |
| SCHEMBL7810309 | 0.70 | TTK (0.72) | TTKKDRMAPK8MAPK9KIT | |
| SCHEMBL9201258 | 0.70 | MEN1 (0.67) | TTKKDRMAPK8MAPK9KIT | |
| SCHEMBL8796647 | 0.70 | MEN1 (0.67) | TTKKDRMAPK8MAPK9KIT | |
| SCHEMBL8336855 | 0.69 | CDK2 (0.65) | TTKKDRMAPK8MAPK9KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0750619-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA S.p.A. (IT) | 1997-01-02 | — | — | EP | disclosed |