Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | FGB | P02675 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9435000 | 0.70 | MAPT (0.32) | TSHRMAPTKMT2AKDM4EMEN1 | |
| SCHEMBL8796993 | 0.69 | — | — | |
| SCHEMBL8153451 | 0.69 | — | — | |
| SCHEMBL8155848 | 0.69 | PDE1C (0.36) | SMN1; SMN2MAPTKMT2AMEN1GAA | |
| SCHEMBL1388444 | 0.69 | FGB (0.38) | TSHRSMN1; SMN2MAPTLMNAHSP90AA1 | |
| SCHEMBL9434368 | 0.68 | SMN1; SMN2 (0.36) | SMN1; SMN2MAPTLMNAHSP90AA1HTT | |
| SCHEMBL9434365 | 0.68 | FGB (0.42) | TSHRSMN1; SMN2MAPTLMNAHSP90AA1 | |
| SCHEMBL9434910 | 0.68 | HRH3 (0.37) | TSHRSMN1; SMN2MAPTLMNAHSP90AA1 | |
| SCHEMBL8797852 | 0.67 | NPC1 (0.31) | SMN1; SMN2RAB9AHPGDNPC1 | |
| SCHEMBL9434110 | 0.66 | SMN1; SMN2 (0.36) | TSHRSMN1; SMN2MAPTLMNAHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0769012-A1 | TETRACYCLIC DERIVATIVES AND THEIR USE AS ANTITUMOUR AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1997-04-23 | — | — | EP | disclosed |
| WO-1996001827-A1 | TETRACYCLIC DERIVATIVES AND THEIR USE AS ANTITUMOUR AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-01-25 | — | — | WO | disclosed |