Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | FGB | P02675 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 2/20 | 0.33 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.32 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9434910 | 0.86 | HRH3 (0.37) | SMN1; SMN2ALDH1A1MAPTHTTLMNA | |
| SCHEMBL8150303 | 0.85 | MAPT (0.41) | SMN1; SMN2ALDH1A1GABRA1GABRB1GABRA3 | |
| SCHEMBL9434110 | 0.84 | SMN1; SMN2 (0.36) | SMN1; SMN2ALDH1A1GABRA1GABRA3MAPT | |
| SCHEMBL9434365 | 0.78 | FGB (0.42) | SMN1; SMN2ALDH1A1MAPTHTTLMNA | |
| SCHEMBL1388444 | 0.77 | FGB (0.38) | SMN1; SMN2ALDH1A1MAPTHTTLMNA | |
| SCHEMBL9435000 | 0.74 | MAPT (0.32) | MAPTMEN1KMT2AKDM4E | |
| SCHEMBL8150574 | 0.73 | LMNA (0.30) | SMN1; SMN2MAPTHTTLMNAHSP90AA1 | |
| SCHEMBL8155848 | 0.72 | PDE1C (0.36) | SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL9435019 | 0.71 | ALDH1A1 (0.35) | SMN1; SMN2ALDH1A1MAPTHTTLMNA | |
| SCHEMBL7963227 | 0.70 | LMNA (0.36) | SMN1; SMN2ALDH1A1MAPTHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994002483-A1 | TETRACYCLIC COMPOUNDS PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOUR AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-02-03 | — | — | WO | disclosed |