Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9434368 | 0.84 | SMN1; SMN2 (0.36) | SMN1; SMN2MAPK1NPSR1MAPTGABRA1 | |
| SCHEMBL9434910 | 0.83 | HRH3 (0.37) | SMN1; SMN2TSHRMAPK1MAPTKDM4E | |
| SCHEMBL9434365 | 0.76 | FGB (0.42) | SMN1; SMN2TSHRMAPTKDM4EALDH1A1 | |
| SCHEMBL1388444 | 0.74 | FGB (0.38) | SMN1; SMN2TSHRMAPK1NPSR1MAPT | |
| SCHEMBL8155848 | 0.72 | PDE1C (0.36) | SMN1; SMN2MAPTGAA | |
| SCHEMBL9435000 | 0.71 | MAPT (0.32) | TSHRMAPTKDM4EPOLB | |
| SCHEMBL9435019 | 0.69 | ALDH1A1 (0.35) | SMN1; SMN2NPSR1MAPTKDM4EALDH1A1 | |
| SCHEMBL8911552 | 0.67 | SMN1; SMN2 (0.36) | SMN1; SMN2NPSR1MAPTKDM4EALDH1A1 | |
| SCHEMBL8147980 | 0.67 | — | — | |
| SCHEMBL8797003 | 0.66 | TSHR (0.37) | SMN1; SMN2TSHRMAPK1NPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994002483-A1 | TETRACYCLIC COMPOUNDS PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOUR AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-02-03 | — | — | WO | disclosed |