Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797400 | 0.85 | NLRP3 (0.39) | NLRP3MAPTSMN1; SMN2LMNA | |
| SCHEMBL8797149 | 0.82 | HTT (0.41) | TP53NLRP3TDP1POLBRAB9A | |
| SCHEMBL8797294 | 0.82 | TP53 (0.38) | TP53NLRP3TDP1POLBRAB9A | |
| SCHEMBL8798206 | 0.79 | NLRP3 (0.37) | NLRP3MAPTROCK2SMN1; SMN2LMNA | |
| SCHEMBL8797985 | 0.71 | NLRP3 (0.35) | NLRP3TDP1MAPTROCK2SMN1; SMN2 | |
| SCHEMBL8798136 | 0.70 | TP53 (0.42) | TP53NLRP3SMN1; SMN2LMNA | |
| SCHEMBL8798200 | 0.69 | TP53 (0.48) | TP53TDP1POLBRAB9AMAPT | |
| SCHEMBL8797278 | 0.69 | TP53 (0.41) | TP53NLRP3TDP1POLBRAB9A | |
| SCHEMBL8797868 | 0.69 | KMT2A (0.40) | TP53NLRP3TDP1HTTSMN1; SMN2 | |
| SCHEMBL8797263 | 0.68 | HDAC4 (0.35) | TP53RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497201-B1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO KK (JP) | 1997-01-15 | — | — | EP | claimed |