⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL221926 | 0.86 | — | — | |
| SCHEMBL8813650 | 0.79 | TP53 (0.30) | — | |
| SCHEMBL223999 | 0.78 | LMNA (0.38) | — | |
| SCHEMBL2680846 | 0.77 | APP (0.41) | — | |
| SCHEMBL8798315 | 0.77 | CA2 (0.35) | — | |
| SCHEMBL6589960 | 0.77 | APP (0.41) | — | |
| SCHEMBL25582562 | 0.73 | LMNA (0.32) | — | |
| SCHEMBL8813031 | 0.73 | TP53 (0.33) | — | |
| SCHEMBL18270680 | 0.71 | LMNA (0.31) | — | |
| SCHEMBL8810682 | 0.71 | ACE2 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763524-A1 | Urea and amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prophylactic use | SANKYO COMPANY LIMITED (JP) | 1997-03-19 | — | — | EP | disclosed |