Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | PTPRC | P08575 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8799009 | 0.90 | CYP11B1 (0.43) | BRD4HPGDCYP17A1LMNAALDH1A1 | |
| SCHEMBL8798345 | 0.86 | BRD4 (0.42) | BRD4HPGDCYP17A1MAPTLMNA | |
| SCHEMBL9230527 | 0.85 | IMPDH2 (0.48) | IMPDH2BRD4HPGDMAPTLMNA | |
| SCHEMBL8796818 | 0.85 | KDM4E (0.33) | HPGDMAPTF2HTR6ALDH1A1 | |
| SCHEMBL8797621 | 0.77 | BRD4 (0.40) | BRD4HPGDCYP17A1MAPTLMNA | |
| SCHEMBL9233065 | 0.75 | CYP11B1 (0.44) | IMPDH2BRD4HPGDMAPTMEN1 | |
| SCHEMBL9271111 | 0.75 | SMN1; SMN2 (0.48) | BRD4HPGDLMNAMEN1KMT2A | |
| SCHEMBL8797664 | 0.75 | HTR6 (0.37) | LMNAHTR6PKMCYP1A2CYP2C9 | |
| SCHEMBL9230530 | 0.71 | BRD4 (0.44) | BRD4HPGDCYP17A1LMNAMEN1 | |
| SCHEMBL8796821 | 0.70 | HTR6 (0.33) | HPGDMAPTHTR6ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0781284-A1 | INDOLE-2,3-DIONE-3-OXIME DERIVATIVES, THEIR PREPARATION AND USE | NEUROSEARCH A/S (DK) | 1997-07-02 | — | — | EP | disclosed |
| WO-1996008494-A1 | INDOLE-2,3-DIONE-3-OXIME DERIVATIVES, THEIR PREPARATION AND USE | NEUROSEARCH A/S (DK) | 1996-03-21 | — | — | WO | disclosed |