Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.36 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8798430 | 0.90 | IMPDH2 (0.43) | BRD4HPGDCYP17A1ALDH1A1LMNA | |
| SCHEMBL9233065 | 0.86 | CYP11B1 (0.44) | CYP11B1CYP11B2KEAP1NFE2L2BRD4 | |
| SCHEMBL8797664 | 0.85 | HTR6 (0.37) | NAMPTLMNA | |
| SCHEMBL8798345 | 0.84 | BRD4 (0.42) | BRD4HPGDCYP17A1GAAALDH1A1 | |
| SCHEMBL9086171 | 0.79 | KCNH2 (0.42) | CYP11B1CYP11B2HPGDCYP17A1GAA | |
| SCHEMBL8797782 | 0.76 | CYP11B2 (0.40) | CYP11B1CYP11B2CYP17A1 | |
| SCHEMBL9230527 | 0.75 | IMPDH2 (0.48) | BRD4HPGDALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8796818 | 0.75 | KDM4E (0.33) | PIK3CAHPGDGAAALDH1A1NAMPT | |
| SCHEMBL8797621 | 0.75 | BRD4 (0.40) | BRD4HPGDCYP17A1ALDH1A1LMNA | |
| SCHEMBL8796991 | 0.74 | POLB (0.40) | CYP11B1CYP11B2KDRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0514942-B1 | Novel benzopyran derivatives and processes for the preparation thereof | KOREA RES INST CHEM TECH (KR) | 1997-03-05 | — | — | EP | disclosed |
| US-5493029-A | USEFUL IN TREATING ASTHMA AND HYPERTENSION | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1996-02-20 | — | — | US | disclosed |
| US-5300511-A | Spiro-benzopyran derivatives and useful for treating asthma and hypertension | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1994-04-05 | — | — | US | disclosed |
| EP-0514942-A1 | Novel benzopyran derivatives and processes for the preparation thereof | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1992-11-25 | — | — | EP | disclosed |