Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP8 | P22894 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4094504 | 0.91 | SIGMAR1 (0.41) | SMN1; SMN2NOS2EPHX2SIGMAR1MMP2 | |
| SCHEMBL245877 | 0.89 | SIGMAR1 (0.44) | SMN1; SMN2EPHX2SIGMAR1MMP2MMP8 | |
| Hydrochloric Acid SCHEMBL30226293 | 0.89 | SIGMAR1 (0.39) | SMN1; SMN2NOS2EPHX2SIGMAR1 | |
| Hydrochloric Acid SCHEMBL11818439 | 0.87 | SIGMAR1 (0.42) | SMN1; SMN2EPHX2SIGMAR1MMP2MMP8 | |
| SCHEMBL4099742 | 0.85 | KDM1A (0.31) | — | |
| Hydrochloric Acid SCHEMBL6264962 | 0.83 | PKM (0.30) | — | |
| SCHEMBL28366731 | 0.82 | EPHX2 (0.38) | EPHX2 | |
| SCHEMBL16762704 | 0.79 | LIPG (0.44) | SIGMAR1 | |
| SCHEMBL20075958 | 0.78 | NOS2 (0.38) | SMN1; SMN2NOS2EPHX2SIGMAR1MMP2 | |
| SCHEMBL1588520 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0527117-B1 | Substituted cyclopropylamino-1,3,5-triazines | UCB SA (BE) | 1997-10-29 | — | — | EP | claimed |
| EP-0527117-A1 | Substituted cyclopropylamino-1,3,5-triazines | U C B, S.A. (BE) | 1993-02-10 | — | — | EP | claimed |
| EP-0527117-B1 | Substituted cyclopropylamino-1,3,5-triazines | UCB SA (BE) | 1997-10-29 | — | — | EP | disclosed |
| US-5348956-A | Antiinflammatory and antiasthmatic agents | UCB S.A. (BE) | 1994-09-20 | — | — | US | disclosed |
| US-5258513-A | FOR TREATMENT OF ALZHEIMER'S DISEASE, SENILE DEMENTIA, EVOLUTIVE COGNITIVE PATHOLOGIES, DEPRESSION, ANXIETY, MOOD DISTURBANCES, INFLAMMATION AND ASTHMA | UCB S.A. (BE) | 1993-11-02 | — | — | US | disclosed |
| EP-0527117-A1 | Substituted cyclopropylamino-1,3,5-triazines | U C B, S.A. (BE) | 1993-02-10 | — | — | EP | disclosed |