Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13376291 | 0.79 | TGM2 (0.36) | KDM4EALDH1A1SMN1; SMN2TGM2CES1 | |
| SCHEMBL633096 | 0.64 | MMP12 (0.65) | ALDH1A1SMN1; SMN2PDE3BPDE3AHPGD | |
| SCHEMBL18307135 | 0.62 | BRD4 (0.50) | KDM4EALDH1A1SMN1; SMN2TGM2CES1 | |
| SCHEMBL8265565 | 0.59 | MMP12 (0.50) | KDM4EALDH1A1SMN1; SMN2PDE3BPDE3A | |
| SCHEMBL14292808 | 0.59 | LMNA (0.43) | KDM4EALDH1A1SMN1; SMN2TGM2CES1 | |
| SCHEMBL656665 | 0.59 | JAK1 (0.40) | KDM4EALDH1A1SMN1; SMN2PDE3BPDE3A | |
| SCHEMBL2144278 | 0.59 | PDK2 (0.55) | TGM2CES1PDE3BPDE3A | |
| SCHEMBL15651034 | 0.57 | ALDH1A1 (0.39) | KDM4EALDH1A1SMN1; SMN2PDE3BPDE3A | |
| SCHEMBL9920477 | 0.57 | KDM4E (0.52) | KDM4EALDH1A1SMN1; SMN2PDE3BPDE3A | |
| SCHEMBL18413652 | 0.57 | TGM2 (0.49) | TGM2CES1PDE3BPDE3APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5700798-A | Methods for using benzoxazines for treating asthma | ZENECA LIMITED (GB) | 1997-12-23 | — | — | US | disclosed |
| EP-0698022-B1 | 1,4-BENZOXAZINE DERIVATIVES AS POTASSIUM CHANNEL OPENERS | ZENECA LTD (GB) | 1997-09-17 | — | — | EP | disclosed |
| EP-0731796-A1 | 1,3,5-TRISUBSTITUTED PYRAZOLE COMPOUNDS FOR TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-09-18 | — | — | EP | disclosed |
| EP-0698022-A1 | 1,4-BENZOXAZINE DERIVATIVES AS POTASSIUM CHANNEL OPENERS | ZENECA LTD (GB) | 1996-02-28 | — | — | EP | disclosed |
| US-5486515-A | 2-fluoroalkyl-1,4-benzoxaxines as potassium channel mediators | ZENECA LIMITED (GB) | 1996-01-23 | — | — | US | disclosed |
| WO-1995015318-A1 | 1,3,5-TRISUBSTITUTED PYRAZOLE COMPOUNDS FOR TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-06-08 | — | — | WO | disclosed |
| WO-1994026739-A1 | 1,4-BENZOXAZINE DERIVATIVES AS POTASSIUM CHANNEL OPENERS | ZENECA LIMITED (GB) | 1994-11-24 | — | — | WO | disclosed |