Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 3/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.44 |
| ▸ | PTGES | O14684 | 2/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8799325 | 0.84 | ALDH1A1 (0.41) | FOLH1PTGESALOX5PPARGALDH1A1 | |
| SCHEMBL8798867 | 0.82 | FOLH1 (0.46) | FOLH1SLC7A5LOXL2MRGPRX4ALDH1A1 | |
| SCHEMBL8464381 | 0.80 | PPARG (0.47) | FOLH1PTGESALOX5PPARGALDH1A1 | |
| SCHEMBL8799635 | 0.78 | CYP4F2 (0.49) | CYP4F2CYP4A11LOXL2FAAH | |
| SCHEMBL8799754 | 0.75 | LTB4R (0.49) | — | |
| SCHEMBL8799424 | 0.73 | MAPT (0.47) | ALDH1A1HPGD | |
| SCHEMBL8799244 | 0.73 | MAPT (0.47) | CYP4F2CYP4A11ALDH1A1HPGD | |
| SCHEMBL9120998 | 0.73 | FOLH1 (0.53) | FOLH1ALDH1A1 | |
| SCHEMBL8800191 | 0.71 | PPARG (0.38) | FOLH1PTGESALOX5PPARGALDH1A1 | |
| SCHEMBL8327593 | 0.71 | PTGER4 (0.62) | CYP4F2CYP4A11LOXL2MRGPRX4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755381-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B 4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028386-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1995-10-26 | — | — | WO | disclosed |