Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 3/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.44 |
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | F10 | P00742 | 2/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.34 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8800056 | 0.86 | ALDH1A1 (0.41) | DHODHSLC16A3ALDH1A1 | |
| SCHEMBL8799650 | 0.81 | CYP4F2 (0.46) | CYP4F2CYP4A11F2F10LOXL2 | |
| SCHEMBL8799885 | 0.78 | CYP4F2 (0.46) | CYP4F2CYP4A11LOXL2FAAH | |
| SCHEMBL8801665 | 0.73 | ALDH1A1 (0.43) | CYP4F2CYP4A11DHODHSLC16A3ALDH1A1 | |
| SCHEMBL5467067 | 0.73 | CYP4F2 (0.64) | CYP4F2CYP4A11LOXL2NR3C1SLC7A5 | |
| SCHEMBL9122491 | 0.72 | KCNA5 (0.41) | ALDH1A1HPGD | |
| SCHEMBL5464169 | 0.70 | FOLH1 (0.47) | CYP4F2CYP4A11FOLH1 | |
| SCHEMBL1794739 | 0.70 | CYP4A11 (0.61) | CYP4F2CYP4A11LOXL2DHODHALDH1A1 | |
| SCHEMBL8732251 | 0.69 | CYP4A11 (0.63) | CYP4F2CYP4A11LOXL2DHODHALDH1A1 | |
| SCHEMBL8799411 | 0.69 | CYP4A11 (0.61) | CYP4F2CYP4A11F2F10LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755381-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B 4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028386-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1995-10-26 | — | — | WO | disclosed |