Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SLC16A3 | O15427 | 3/20 | 0.34 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.33 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8800056 | 0.87 | ALDH1A1 (0.41) | ALDH1A1LMNADHODHPOLBHSD17B10 | |
| SCHEMBL2655008 | 0.80 | ALDH1A1 (0.62) | ALDH1A1LMNADHODHCYP4A11CYP4F2 | |
| SCHEMBL5253878 | 0.80 | ALDH1A1 (0.62) | ALDH1A1LMNADHODHCYP4A11CYP4F2 | |
| SCHEMBL3554041 | 0.79 | ALDH1A1 (0.64) | ALDH1A1LMNADHODHCYP4A11CYP4F2 | |
| SCHEMBL8800306 | 0.77 | ALDH1A1 (0.44) | ALDH1A1LMNADHODHCYP4A11CYP4F2 | |
| SCHEMBL383349 | 0.75 | ALDH1A1 (0.66) | ALDH1A1LMNADHODHCYP4A11CYP4F2 | |
| SCHEMBL8799647 | 0.73 | CYP4F2 (0.44) | ALDH1A1DHODHCYP4A11CYP4F2SLC16A3 | |
| SCHEMBL8800299 | 0.73 | LTB4R (0.50) | ALDH1A1LMNADHODH | |
| SCHEMBL10499238 | 0.73 | LMNA (0.63) | ALDH1A1LMNADHODHCYP4A11CYP4F2 | |
| SCHEMBL9120711 | 0.72 | KCNA5 (0.41) | ALDH1A1CYP4A11CYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755381-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B 4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028386-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1995-10-26 | — | — | WO | disclosed |