Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 4/20 | 0.50 |
| ▸ | REN | P00797 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CPA1 | P15085 | 2/20 | 0.45 |
| ▸ | CPA3 | P15088 | 2/20 | 0.45 |
| ▸ | CPB1 | P15086 | 1/20 | 0.45 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.45 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | TACR3 | P29371 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | ANPEP | P15144 | 1/20 | 0.42 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.42 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7288419 | 1.00 | TACR2 (0.50) | TACR2RENALDH1A1CPA1CPA3 | |
| SCHEMBL7303707 | 0.90 | SIGMAR1 (0.51) | CPA1CPA3CPB1CPB2CYP1A2 | |
| SCHEMBL7326577 | 0.90 | SIGMAR1 (0.51) | CPA1CPA3CPB1CPB2CYP1A2 | |
| SCHEMBL8449054 | 0.88 | HRH3 (0.52) | CPA1CPA3CPB1CPB2SIGMAR1 | |
| SCHEMBL8800452 | 0.88 | ALDH1A1 (0.47) | TACR2RENALDH1A1KMT2APOLB | |
| SCHEMBL7351373 | 0.84 | CPA1 (0.47) | CPA1CPA3CPB1CPB2CYP1A2 | |
| SCHEMBL7292894 | 0.80 | TACR2 (0.49) | TACR2REN | |
| SCHEMBL7280064 | 0.78 | CPA1 (0.57) | CPA1CPA3CPB1CPB2CYP1A2 | |
| SCHEMBL9556513 | 0.77 | REN (0.50) | TACR2RENTACR1TACR3 | |
| SCHEMBL7281033 | 0.77 | CPA1 (0.55) | ALDH1A1CPA1CPA3CPB1CPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0655062-B1 | MORPHOLINO/THIOMORPHOLINO-TERMINATED ALKYLAMINO ETHYNYL ALANINE AMINO DIOL COMPOUNDS AS RENIN INHIBITORS | SEARLE & CO (US) | 1997-10-08 | — | — | EP | disclosed |
| US-5422349-A | Renin inhibitors | G. D. SEALE & CO. (US) | 1995-06-06 | — | — | US | disclosed |
| US-5416084-A | Benzo-fused thiomorpholinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension | G.D. SEARLE & CO. (US) | 1995-05-16 | — | — | US | disclosed |
| US-5413998-A | Oligopeotide derivatives as renin inhibitors | G. D. SEARLE & CO. (US) | 1995-05-09 | — | — | US | disclosed |
| US-5411950-A | Benzo-fused oxazocinyl terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension | G. D. SEARLE & CO. (US) | 1995-05-02 | — | — | US | disclosed |
| US-5411953-A | Oxazopinyl terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension | G. D. SEARLE & CO. (US) | 1995-05-02 | — | — | US | disclosed |
| US-5411954-A | Enzyme inhibitors | G. D. SEARLE & CO. (US) | 1995-05-02 | — | — | US | disclosed |
| US-5409925-A | Renin inhibitors | G. D. SEARL & CO. (US) | 1995-04-25 | — | — | US | disclosed |
| US-5409924-A | Renin inhibitors | G. D. SEARLE & CO. (US) | 1995-04-25 | — | — | US | disclosed |
| US-5409922-A | Renin inhibitors | G. D. SEARLE & CO. (US) | 1995-04-25 | — | — | US | disclosed |
| US-5409945-A | Benzyo-fused thiazolidinyl terminated alkylamino ethylnyl alanine amino diol compounds for treatment of hypertension | G. D. SEARLE & CO. (US) | 1995-04-25 | — | — | US | disclosed |
| US-5409913-A | Renin inhibitors | Keane, J. Timothy (US) | 1995-04-25 | — | — | US | disclosed |
| WO-1989010751-A1 | FUNCTIONALIZED PEPTIDYL AMINODIOLS AND -TRIOLS | ABBOTT LABORATORIES (US) | 1989-11-16 | — | — | WO | disclosed |