Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 6/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.49 |
| ▸ | PLAU | P00749 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7901142 | 0.86 | NR4A2 (0.74) | NR4A2PTPN1MAOBSMPD1SRD5A2 | |
| SCHEMBL11639201 | 0.84 | ERCC5 (0.62) | NR4A2PTPN1MAOBSMPD1SRD5A2 | |
| SCHEMBL4708458 | 0.83 | ERCC5 (0.65) | NR4A2PTPN1MAOBSRD5A2PLAU | |
| SCHEMBL1515775 | 0.81 | MEN1 (0.61) | MRGPRX4MEN1KMT2AL3MBTL1HSD11B1 | |
| SCHEMBL5009881 | 0.80 | NR4A2 (0.65) | NR4A2SRD5A2MRGPRX4KMT2A | |
| SCHEMBL9671290 | 0.78 | ERCC5 (0.63) | NR4A2PTPN1MAOBERCC5FEN1 | |
| SCHEMBL9526431 | 0.77 | NR4A2 (0.69) | NR4A2PTPN1MAOBSMPD1SRD5A2 | |
| SCHEMBL7914285 | 0.76 | L3MBTL1 (0.61) | NR4A2PTPN1MAOBSMPD1MRGPRX4 | |
| SCHEMBL1515848 | 0.76 | CES2 (0.55) | NR4A2SRD5A2PLAUMEN1KMT2A | |
| SCHEMBL27674694 | 0.76 | NR4A2 (0.46) | NR4A2MAOBSMPD1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0809636-A1 | SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-12-03 | — | — | EP | disclosed |
| WO-1996025405-A1 | SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-22 | — | — | WO | disclosed |