Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP15 | Q460N3 | 1/20 | 0.49 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.49 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | TYMS | P04818 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78785 | 0.87 | ALDH1A1 (0.53) | PARP15PARP10TNKS2MAPTHSD17B10 | |
| SCHEMBL18122808 | 0.81 | MAOA (0.59) | PARP15PARP10TNKS2MAPTHSD17B10 | |
| SCHEMBL28407033 | 0.75 | ALDH1A1 (0.48) | MAPTALDH1A1KDM4EMAOALMNA | |
| SCHEMBL8807789 | 0.72 | ALDH1A1 (0.46) | MAPTHSD17B10ALDH1A1KDM4ETSHR | |
| SCHEMBL3868022 | 0.72 | MAPT (0.53) | MAPTHSD17B10ALDH1A1KDM4EMEN1 | |
| SCHEMBL18122812 | 0.70 | ALDH1A1 (0.49) | MAPTHSD17B10ALDH1A1KDM4EMEN1 | |
| SCHEMBL6231819 | 0.70 | MAPT (0.43) | MAPTHSD17B10ALDH1A1KDM4EMAOA | |
| SCHEMBL274964 | 0.69 | KDM4E (0.70) | MAPTHSD17B10ALDH1A1KDM4EMEN1 | |
| SCHEMBL18074682 | 0.68 | LMNA (0.53) | MAPTALDH1A1KDM4EMAOALMNA | |
| SCHEMBL79949 | 0.68 | LMNA (0.53) | MAPTALDH1A1KDM4EMAOALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755392-A4 | ALPHA1C ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1997-05-02 | — | — | EP | disclosed |
| EP-0755392-A1 | ALPHA1C ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO. INC. (US) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028397-A1 | ALPHA1C ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1995-10-26 | — | — | WO | disclosed |