Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 2/20 | 0.79 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.79 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 7/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL685515 | 0.88 | AGTR1 (1.00) | AGTR1AGTR2PPARG | |
| SCHEMBL30838455 | 0.88 | AGTR1 (1.00) | AGTR1AGTR2PPARG | |
| SCHEMBL20017271 | 0.86 | AGTR1 (0.80) | AGTR1AGTR2NOS1NOS2PPARG | |
| SCHEMBL8972527 | 0.85 | AGTR1 (0.93) | AGTR1AGTR2NOS1NOS2PPARG | |
| SCHEMBL8958505 | 0.84 | AGTR1 (0.81) | AGTR1AGTR2NOS1NOS2PPARG | |
| SCHEMBL9847827 | 0.81 | AGTR2 (0.69) | AGTR1AGTR2NOS1NOS2PPARG | |
| SCHEMBL20860208 | 0.79 | AGTR1 (0.82) | AGTR1AGTR2NOS1NOS2PPARG | |
| SCHEMBL8802161 | 0.79 | AGTR1 (0.82) | AGTR1AGTR2PPARG | |
| SCHEMBL14062533 | 0.79 | AGTR1 (0.82) | AGTR1AGTR2NOS1NOS2PPARG | |
| SCHEMBL9847862 | 0.77 | AGTR1 (0.71) | AGTR1AGTR2NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628557-B1 | Biphenylmethane derivatives, the use of them and pharmacological compositions containing same | EISAI CO LTD (JP) | 1997-05-02 | — | — | EP | claimed |
| EP-0628557-A1 | Biphenylmethane derivatives, the use of them and pharmacological compositions containing same | Eisai Co., Ltd. (JP) | 1994-12-14 | — | — | EP | claimed |
| US-5506238-A | HYPOTENSIVE AGENT | EISAI CO., LTD. (JP) | 1996-04-09 | — | — | US | disclosed |
| EP-0628557-A1 | Biphenylmethane derivatives, the use of them and pharmacological compositions containing same | Eisai Co., Ltd. (JP) | 1994-12-14 | — | — | EP | disclosed |
| US-5328911-A | Cardiovascular disorders, hypotensive agents and congestive heart failure | EISAI CO., LTD. (JP) | 1994-07-12 | — | — | US | disclosed |
| EP-0598702-A1 | Biphenylmethane derivative, the use of it and pharmacological compositions containing same | Eisai Co., Ltd. (JP) | 1994-05-25 | — | — | EP | disclosed |
| US-5298518-A | Biphenylmethane derivative and pharmacological use | EISAI CO., LTD. (JP) | 1994-03-29 | — | — | US | disclosed |