Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | FPR1 | P21462 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8802745 | 0.86 | MEN1 (0.55) | KMT2AMEN1NPC1RAB9ALMNA | |
| SCHEMBL7983845 | 0.80 | LMNA (0.50) | KMT2AMEN1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8803269 | 0.80 | LMNA (0.39) | KMT2AMEN1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8802957 | 0.79 | ESRRB (0.38) | KMT2ASMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL29249095 | 0.76 | MEN1 (0.51) | KMT2AMEN1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL31643682 | 0.73 | NUAK1 (0.36) | KMT2AMEN1HTTALDH1A1KDM4E | |
| SCHEMBL15444574 | 0.71 | NUAK1 (0.35) | KMT2AMEN1ALDH1A1KDM4EHPGD | |
| SCHEMBL29249103 | 0.69 | ESR1 (0.52) | KMT2AMEN1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL29249066 | 0.68 | MEN1 (0.51) | KMT2AMEN1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL9693861 | 0.64 | ALDH1A1 (0.54) | KMT2AMEN1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0778769-A1 | USE OF 5-SUBSTITUTED PYRIDINE AND HEXAHYDROQUINOLINE-3 CARBOXYLIC ACID DERIVATIVES FOR TREATING DISEASES OF THE CENTRAL NERVOUS SYSTEM | BAYER AG (DE) | 1997-06-18 | — | — | EP | claimed |
| WO-1996006610-A1 | USE OF 5-SUBSTITUTED PYRIDINE AND HEXAHYDROQUINOLINE-3 CARBOXYLIC ACID DERIVATIVES FOR TREATING DISEASES OF THE CENTRAL NERVOUS SYSTEM | BAYER AKTIENGESELLSCHAFT (DE) | 1996-03-07 | — | — | WO | claimed |