Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7978016 | 0.83 | PLA2G2A (0.47) | LMNAALDH1A1PLA2G2ASMN1; SMN2NPC1 | |
| SCHEMBL11015788 | 0.82 | SMN1; SMN2 (0.44) | LMNAALDH1A1SMN1; SMN2NPC1MAPT | |
| SCHEMBL7984066 | 0.80 | POLB (0.44) | LMNAALDH1A1SMN1; SMN2MAPTTP53 | |
| SCHEMBL8801276 | 0.80 | KMT2A (0.41) | LMNAALDH1A1SMN1; SMN2NPC1MAPT | |
| SCHEMBL30209788 | 0.79 | KDM4E (0.61) | LMNAALDH1A1PLA2G2ASMN1; SMN2NPC1 | |
| SCHEMBL7979237 | 0.79 | LMNA (0.53) | LMNAALDH1A1PLA2G2ASMN1; SMN2NPC1 | |
| SCHEMBL8803269 | 0.79 | LMNA (0.39) | LMNAALDH1A1PLA2G2ASMN1; SMN2NPC1 | |
| SCHEMBL11009673 | 0.78 | ALDH1A1 (0.55) | LMNAALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL7979351 | 0.77 | LMNA (0.80) | LMNAALDH1A1PLA2G2ASMN1; SMN2NPC1 | |
| SCHEMBL7977550 | 0.76 | NR3C2 (0.39) | PLA2G2ASMN1; SMN2NPC1RAB9AABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194428-B1 | BRAIN DISORDERS; PSYCHOLOGICAL DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 2001-02-27 | — | — | US | disclosed |