Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8800267 | 0.74 | HRH4 (0.30) | HRH4 | |
| SCHEMBL563046 | 0.73 | ALDH1A1 (0.46) | MAPTALDH1A1GAABRD4LMNA | |
| SCHEMBL8801148 | 0.71 | — | — | |
| SCHEMBL562165 | 0.69 | ALDH1A1 (0.49) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL562684 | 0.68 | ALDH1A1 (0.50) | MAPTTSHRALDH1A1LMNACYP1A2 | |
| SCHEMBL10667815 | 0.65 | CYP1A2 (0.36) | MAPTTSHRALDH1A1GAACYP1A2 | |
| SCHEMBL8801218 | 0.62 | — | — | |
| SCHEMBL9821407 | 0.61 | CA12 (0.52) | MAPTGAABRD4KMT2A | |
| SCHEMBL4480012 | 0.61 | L3MBTL1 (0.63) | MAPTTSHRALDH1A1GAALMNA | |
| SCHEMBL10555250 | 0.59 | CA12 (0.40) | MAPTALDH1A1GAALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0580916-B1 | N(1) substituted pyrazino [2,3-c]-1,2,6-thiadiazine 2,2-dioxides and their use as pharmaceuticals | PRODESFARMA SA (ES) | 1997-03-05 | — | — | EP | disclosed |