Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 10/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CCKAR | P32238 | 3/20 | 0.40 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8801634 | 0.81 | CCKBR (0.41) | CCKBRKCNH2CCKARHDAC3HDAC1 | |
| SCHEMBL8801839 | 0.78 | CCKBR (0.50) | CCKBRCCKAR | |
| SCHEMBL8800232 | 0.76 | OXTR (0.49) | CCKBRKCNH2CCKAR | |
| SCHEMBL8800784 | 0.74 | CCKBR (0.46) | CCKBRKCNH2CCKARSENP1 | |
| SCHEMBL8800767 | 0.74 | CCKBR (0.44) | CCKBRCCKAR | |
| SCHEMBL8669120 | 0.73 | CCKBR (0.44) | CCKBRKCNH2CCKAR | |
| SCHEMBL8801061 | 0.73 | FNTA (0.46) | CCKBRKCNH2CCKARHDAC3HDAC1 | |
| SCHEMBL8801333 | 0.72 | FNTA (0.52) | CCKBRCCKAR | |
| SCHEMBL8674499 | 0.71 | CCKBR (0.46) | CCKBRKCNH2CCKARHDAC3HDAC1 | |
| SCHEMBL8674221 | 0.71 | CCKBR (0.51) | CCKBRKCNH2CCKARSENP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994026723-A2 | ras FARNESYL TRANSFERASE INHIBITORS | GENENTECH, INC. (US) | 1994-11-24 | — | — | WO | claimed |
| EP-0763537-A2 | Non-peptidyl Ras farnesyl transferase inhibitors | GENENTECH, INC. (US) | 1997-03-19 | — | — | EP | disclosed |
| EP-0698015-A1 | PREPARATION OF N-CYANODITHIOIMINO-CARBONATES AND 3-MERCAPTO-5-AMINO-1H-1,2,4-TRIAZOLE | GENENTECH, INC. (US) | 1996-02-28 | — | — | EP | disclosed |
| WO-1994026723-A2 | ras FARNESYL TRANSFERASE INHIBITORS | GENENTECH, INC. (US) | 1994-11-24 | — | — | WO | disclosed |