Sugi Predict

Sugi Predict / Compounds / SCHEMBL6740267

SCHEMBL6740267

SCHEMBL6740267

Cc1ncccc1-c1[nH]c(C(F)(F)F)nc1-c1cc(F)c(S(C)(=O)=O)cc1F

nearest known ligand 0.39

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ PTGS2 P35354 3/20 0.39
▸ NR1H2 P55055 3/20 0.39
▸ NR1H3 Q13133 3/20 0.39
▸ HCAR2 Q8TDS4 1/20 0.34
▸ BRAF P15056 6/20 0.34
▸ MAPK14 Q16539 2/20 0.34
▸ GRM4 Q14833 2/20 0.34
▸ PTGS1 P23219 1/20 0.34
▸ ALOX5 P09917 1/20 0.34
▸ PDE2A O00408 1/20 0.33
▸ PDE10A Q9Y233 1/20 0.33
▸ TDO2 P48775 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6729205 0.88 PTGS2 (0.37) PTGS2NR1H2NR1H3BRAFMAPK14
SCHEMBL6722679 0.86 ALOX5 (0.39) PTGS2NR1H2NR1H3MAPK14GRM4
SCHEMBL6729506 0.85 MAPK14 (0.36) PTGS2NR1H2NR1H3BRAFMAPK14
SCHEMBL6739929 0.84 ESR1 (0.48) PTGS2NR1H2NR1H3MAPK14PTGS1
SCHEMBL6733479 0.83 PTGS2 (0.41) PTGS2NR1H2NR1H3PTGS1ALOX5
SCHEMBL6732826 0.83 GRM4 (0.34) PTGS2NR1H2NR1H3GRM4PTGS1
SCHEMBL6736839 0.83 MAPK14 (0.39) NR1H2NR1H3BRAFMAPK14ALOX5
SCHEMBL6736814 0.83 PTGS2 (0.40) PTGS2NR1H2NR1H3BRAFMAPK14
SCHEMBL6738959 0.82 NR1H2 (0.35) PTGS2NR1H2NR1H3BRAFMAPK14
SCHEMBL6734567 0.82 SDHB (0.42) PTGS2NR1H2NR1H3MAPK14PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6699884-B2 ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. PHARMACIA CORPORATION 2004-03-02 — — US claimed
US-20040138261-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation PHARMACIA CORPORATION 2004-07-15 — — US disclosed
US-6699884-B2 ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. PHARMACIA CORPORATION 2004-03-02 — — US disclosed
US-6673818-B2 TREATING CYCLOOXYGENASE-2 MEDIATED DISORDERS, SUCH AS ARTHRITIS, PAIN, FEVER AND CANCER PHARMACIA CORPORATION 2004-01-06 — — US disclosed
US-20030149078-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation PHARMACIA CORPORATION 2003-08-07 — — US disclosed
US-20030032657-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation PHARMACIA CORPORATION 2003-02-13 — — US disclosed
EP-1251126-A2 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation Pharmacia Corporation (US) 2002-10-23 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040138261-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation FPR1, FPR2, FPR3 PTGS2 10/4885NR1H2 173/4885NR1H3 299/4885
US-20030149078-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation FPR1, FPR2, FPR3 PTGS2 10/4885NR1H2 173/4885NR1H3 299/4885
US-20030032657-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation FPR1, FPR2, FPR3 PTGS2 10/4885NR1H2 173/4885NR1H3 299/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.