Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.63 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.61 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3690098 | 0.92 | ALDH1A1 (0.59) | CYP3A4MAPTTDP1ALDH1A1TP53 | |
| Hydrochloric Acid SCHEMBL408084 | 0.91 | ALDH1A1 (0.58) | CYP3A4MAPTTDP1ALDH1A1TP53 | |
| SCHEMBL8805033 | 0.88 | KDM4E (0.53) | CYP3A4MAPTTDP1ALDH1A1TP53 | |
| SCHEMBL10725134 | 0.86 | CYP3A4 (0.64) | CYP3A4MAPTTDP1ALDH1A1TP53 | |
| SCHEMBL8803211 | 0.86 | CYP19A1 (0.54) | CYP3A4MAPTTDP1ALDH1A1TP53 | |
| SCHEMBL10643088 | 0.85 | CYP3A4 (0.63) | CYP3A4MAPTTDP1ALDH1A1TP53 | |
| SCHEMBL8804766 | 0.83 | CYP2A6 (0.55) | CYP3A4TDP1ALDH1A1TP53CYP1A2 | |
| SCHEMBL8805939 | 0.83 | CYP19A1 (0.63) | CYP19A1 | |
| SCHEMBL10643239 | 0.83 | AGER (0.53) | CYP3A4MAPTCYP1A2TBXAS1CYP2D6 | |
| SCHEMBL10642686 | 0.82 | TBXAS1 (0.73) | CYP3A4MAPTTDP1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0492474-B1 | 1,3-Dioxolane derivatives as cholesterol-lowering agents | SYNTEX INC (US) | 1997-03-05 | — | — | EP | disclosed |
| US-5158949-A | 1,3-DIOXOLANE DERIVATIVES AS CHOLESTEROL-LOWERING AGENTS | SYNTEX (U.S.A.) INC. (US) | 1992-10-27 | — | — | US | disclosed |
| EP-0492474-A1 | 1,3-Dioxolane derivatives as cholesterol-lowering agents | SYNTEX (U.S.A.) INC. (US) | 1992-07-01 | — | — | EP | disclosed |
| US-4758573-A | Heterocyclic group-containing compounds | G. D. SEARLE & CO. (US) | 1988-07-19 | — | — | US | disclosed |
| EP-0105575-B1 | 1-(1H-IMIDAZOLYL), 1-N-MORPHOLINYL AND PYRIDYL COMPOUNDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | G.D. Searle & Co. (US) | 1987-03-04 | — | — | EP | disclosed |
| US-4579862-A | TREATMENT OF CEREBROVASCULAR DISEACE, ISCHEMIA, DIABETES, ANGINA, MYOCARDIAL INFARCTION | G. D. SEARLE & CO. (US) | 1986-04-01 | — | — | US | disclosed |
| EP-0105575-A1 | 1-(1H-imidazolyl), 1-N-morpholinyl and pyridyl compounds, their preparation and pharmaceutical compositions containing them | G.D. Searle & Co. (US) | 1984-04-18 | — | — | EP | disclosed |