Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CCR3 | P51677 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8804251 | 0.85 | SOAT2 (0.50) | KMT2AKDM4EMEN1CYP3A4CYP2C19 | |
| SCHEMBL8805028 | 0.76 | SLC6A3 (0.43) | KMT2ASLC6A3SLC6A4MEN1RAB9A | |
| SCHEMBL8805284 | 0.76 | CFD (0.48) | KMT2AKDM4EMEN1CCR3GSK3B | |
| SCHEMBL8804419 | 0.76 | KMT2A (0.46) | KMT2AKDM4EMEN1TSHRCYP1A2 | |
| SCHEMBL8804874 | 0.75 | MAOB (0.49) | KMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8804953 | 0.73 | TRPV1 (0.49) | KMT2AMEN1CCR3RAB9ANPC1 | |
| SCHEMBL8803511 | 0.73 | GAA (0.55) | KMT2AKDM4EMEN1TSHRCYP1A2 | |
| SCHEMBL8803749 | 0.73 | MAOB (0.44) | KMT2AMEN1CCR3CYP1A2CYP2D6 | |
| SCHEMBL8804312 | 0.73 | ALDH1A1 (0.51) | KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8805315 | 0.72 | POLB (0.60) | KMT2AMEN1SMN1; SMN2USP2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625507-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-07-23 | — | — | EP | disclosed |
| US-5621010-A | ANTIHYPERCHOLESTEROLEMIA AND ANTIATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1997-04-15 | — | — | US | disclosed |
| EP-0625507-A2 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1994-11-23 | — | — | EP | disclosed |