Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | CTSG | P08311 | 1/20 | 0.34 |
| ▸ | CMA1 | P23946 | 1/20 | 0.34 |
| ▸ | CTRC | Q99895 | 1/20 | 0.34 |
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11048801 | 0.79 | SIGMAR1 (0.41) | SIGMAR1GSK3AGSK3BMGLLMC4R | |
| SCHEMBL25379874 | 0.79 | LMNA (0.41) | SIGMAR1GSK3AGSK3BMGLLF2 | |
| Bromide SCHEMBL29099282 | 0.77 | SIGMAR1 (0.38) | SIGMAR1GSK3AGSK3BMGLLF2 | |
| Bromide SCHEMBL28711468 | 0.76 | SIGMAR1 (0.37) | SIGMAR1GSK3AGSK3BMGLLF2 | |
| SCHEMBL5969762 | 0.76 | ADRA1D (0.38) | TSHRALDH1A1 | |
| SCHEMBL5174444 | 0.75 | SIGMAR1 (0.36) | SIGMAR1GSK3AGSK3BMGLLF2 | |
| SCHEMBL30631716 | 0.75 | SIGMAR1 (0.36) | SIGMAR1GSK3AGSK3BMGLLMC4R | |
| SCHEMBL23036031 | 0.75 | LMNA (0.42) | SIGMAR1GSK3AGSK3BMGLLF2 | |
| SCHEMBL10619250 | 0.75 | SIGMAR1 (0.36) | SIGMAR1GSK3AGSK3BMGLLF2 | |
| Bromide SCHEMBL30533153 | 0.74 | SIGMAR1 (0.38) | SIGMAR1GSK3AGSK3BMGLLF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1688573-A | Pyrrole based inhibitors of glycogen synthase kinase 3 | CHIRON CORP (US) | 2005-10-26 | — | — | CN | disclosed |
| EP-0625507-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-07-23 | — | — | EP | disclosed |
| US-5621010-A | ANTIHYPERCHOLESTEROLEMIA AND ANTIATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1997-04-15 | — | — | US | disclosed |
| EP-0625507-A2 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1994-11-23 | — | — | EP | disclosed |