Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 2/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17848050 | 0.78 | PIK3CB (0.44) | PKM | |
| SCHEMBL8804551 | 0.78 | PKM (0.36) | PKMKMOSLC9A1MAPK1PDE4B | |
| SCHEMBL21780866 | 0.70 | KMO (0.46) | PKMKMOSLC9A1PLA2G4A | |
| SCHEMBL8803921 | 0.69 | SLC9A1 (0.40) | PKMKMOSLC9A1 | |
| SCHEMBL13641433 | 0.69 | PKM (0.38) | PKMKMOSLC9A1 | |
| SCHEMBL861732 | 0.68 | CYP1A2 (0.57) | KMOSLC9A1 | |
| SCHEMBL13641471 | 0.68 | HTR2A (0.43) | PKMKMOSLC9A1PDE4BPDE4D | |
| SCHEMBL20083775 | 0.67 | CYP1A2 (0.55) | KMOSLC9A1 | |
| SCHEMBL29117331 | 0.67 | CYP1A2 (0.55) | KMOSLC9A1 | |
| SCHEMBL5187580 | 0.67 | CACNA1H (0.45) | PKMKMOPLA2G4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0681581-B1 | SUBSTITUTED FUSED PYRAZOLO COMPOUNDS AND THEIR USE AS HERBICIDES | ZENECA LTD (GB) | 1997-09-10 | — | — | EP | disclosed |
| US-5430007-A | Certain herbicidal pyrazolopyridazines | ZENECA LIMITED (GB) | 1995-07-04 | — | — | US | disclosed |
| WO-1994017062-A1 | SUBSTITUTED FUSED PYRAZOLO COMPOUNDS AND THEIR USE AS HERBICIDES | ZENECA LIMITED (GB) | 1994-08-04 | — | — | WO | disclosed |
| US-5300478-A | Herbicides | ZENECA LIMITED (GB) | 1994-04-05 | — | — | US | disclosed |