SCHEMBL8808484

SCHEMBL8808484

Cc1c(CC(=O)O)c(=O)oc2cc(N)c(S(=O)(=O)O)cc12

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.52
KMT2A Q03164 6/20 0.51
CA12 O43570 4/20 0.50
CA9 Q16790 4/20 0.50
POLB P06746 2/20 0.50
MTOR P42345 1/20 0.45
MEN1 O00255 4/20 0.42
LMNA P02545 1/20 0.42
ALDH1A1 P00352 2/20 0.42
HPGD P15428 2/20 0.42
GLA P06280 1/20 0.42
GAA P10253 1/20 0.42
TSHR P16473 1/20 0.42
CASP1 P29466 1/20 0.42
CASP7 P55210 1/20 0.42
HSD17B10 Q99714 1/20 0.42
NPC1 O15118 1/20 0.42
TP53 P04637 1/20 0.41
NFKB1 P19838 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14579885 1.00 KDM4E (0.52) KDM4EKMT2ACA12CA9POLB
SCHEMBL19603987 0.91 KDM4E (0.42) KDM4EKMT2ACA12CA9POLB
SCHEMBL14161472 0.90 KDM4E (0.41) KDM4EKMT2ACA12CA9POLB
SCHEMBL23155090 0.88 KDM4E (0.40) KDM4EKMT2ACA12CA9POLB
SCHEMBL15788790 0.87 TP53 (0.43) KMT2ACA12CA9MEN1NPC1
SCHEMBL19033045 0.87 NPC1 (0.41) KDM4EKMT2ACA12CA9POLB
SCHEMBL23762520 0.86 KDM4E (0.39) KDM4EKMT2ACA12CA9POLB
SCHEMBL17695455 0.86 KDM4E (0.46) KDM4EKMT2ACA12CA9MEN1
SCHEMBL8814350 0.84 RAB9A (0.56) KMT2AMEN1NPC1TP53
SCHEMBL17088977 0.83 KDM4E (0.60) KDM4EKMT2ACA12CA9POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116615556-A Use of DEXTRAMER in single cell assays 贝克顿迪金森公司 2023-08-18 CN claimed
US-9902986-B2 Enterobactin conjugates and uses thereof MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2018-02-27 US claimed
US-9879041-B2 Saccharide dendritic cluster compounds as inhibitors of BACE-1 VICTORIA LINK LIMITED (NZ) 2018-01-30 US claimed
US-9828341-B2 Dendritic core compounds VICTORIA LINK LIMITED (NZ) 2017-11-28 US claimed
US-20170152279-A9 Saccharide Dendritic Cluster Compounds as Inhibitors of Bace-1 UNIVERSITY OF LIVERPOOL (GB) 2017-06-01 US claimed
US-20150291522-A1 DENDRITIC CORE COMPOUNDS CALLAGHAN INNOVATION RESEARCH LIMITED (NZ) 2015-10-15 US claimed
US-20150291644-A1 Saccharide Dendritic Cluster Compounds as Inhibitors of Bace-1 VICTORIA LINK LTD (NZ) 2015-10-15 US claimed
EP-2925769-A1 SACCHARIDE DENDRITIC CLUSTER COMPOUNDS AS INHIBITORS OF BACE-1 Victoria Link Limited (NZ) 2015-10-07 EP claimed
EP-2925722-A1 DENDRITIC CORE COMPOUNDS Victoria Link Limited (NZ) 2015-10-07 EP claimed
WO-2014084744-A1 SACCHARIDE DENDRITIC CLUSTER COMPOUNDS AS INHIBITORS OF BACE-1 CALLAGHAN INNOVATION RESEARCH LIMITED (NZ) 2014-06-05 WO claimed
WO-2014084743-A1 DENDRITIC CORE COMPOUNDS CALLAGHAN INNOVATION RESEARCH LIMITED (NZ) 2014-06-05 WO claimed
US-20260077067-A1 IMAGING COMPOUNDS FOR DETECTING OR IMAGING SENESCENT CELLS UNIV DUNDEE (GB) 2026-03-19 US disclosed
US-12496361-B2 Imaging compounds for detecting or imaging senescent cells UNIVERSITY OF DUNDEE (GB) 2025-12-16 US disclosed
EP-4649113-A1 IMAGING COMPOUNDS FOR DETECTING OR IMAGING SENESCENT CELLS University Of Dundee (GB) 2025-11-19 EP disclosed
US-20250114483-A1 IMAGING COMPOUNDS FOR DETECTING OR IMAGING SENESCENT CELLS UNIVERSITY OF DUNDEE (GB) 2025-04-10 US disclosed
US-20100317045-A1 COMPOUNDS USED AS DYES COMPERABLE TO ALEXA FLUOR 350 DYES PIERCE BIOTECHNOLOGY, INC. (US) 2010-12-16 US disclosed
US-7799926-B2 Polar dyes CEPHEID (US) 2010-09-21 US disclosed
US-20090004753-A1 LABELING REAGENTS AND METHODS OF THEIR USE INVITROGEN CORPORATION (US) 2009-01-01 US disclosed
US-7179655-B2 Protein profiling platform ACTIVX BIOSCIENCES, INC. (US) 2007-02-20 US disclosed
US-5696157-A Sulfonated derivatives of 7-aminocoumarin MOLECULAR PROBES, INC. (US) 1997-12-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150291522-A1 DENDRITIC CORE COMPOUNDS FLOT1, DBN1, DCTN3 KDM4E 2299/4885KMT2A 3717/4885CA12 1291/4885
US-20100317045-A1 COMPOUNDS USED AS DYES COMPERABLE TO ALEXA FLUOR 350 DYES ACR, RO60, ARF5 KDM4E 2307/4885KMT2A 1086/4885CA12 1709/4885
US-20150291644-A1 Saccharide Dendritic Cluster Compounds as Inhibitors of Bace-1 BACE1, BACE2, APP KDM4E 3260/4885KMT2A 4255/4885CA12 836/4885
US-20260077067-A1 IMAGING COMPOUNDS FOR DETECTING OR IMAGING SENESCENT CELLS NR0B1, NR4A3, NCOA4 KDM4E 3386/4885KMT2A 4627/4885CA12 2960/4885
US-20170152279-A9 Saccharide Dendritic Cluster Compounds as Inhibitors of Bace-1 BACE1, BACE2, APP KDM4E 3260/4885KMT2A 4255/4885CA12 836/4885
US-12496361-B2 Imaging compounds for detecting or imaging senescent cells LIMS1, GLA, TP53 KDM4E 3732/4885KMT2A 4512/4885CA12 2773/4885
US-20250114483-A1 IMAGING COMPOUNDS FOR DETECTING OR IMAGING SENESCENT CELLS LIMS1, GLA, TP53 KDM4E 3732/4885KMT2A 4512/4885CA12 2773/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.