Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8811233 | 0.85 | KCNH2 (0.56) | HRH3POLBCXCR4PARP1CD274 | |
| SCHEMBL8810061 | 0.82 | HRH3 (0.59) | HRH3POLBCXCR4PARP1HDAC1 | |
| SCHEMBL8808913 | 0.77 | HRH3 (0.50) | HRH3POLBOPRM1OPRK1CXCR4 | |
| SCHEMBL8807968 | 0.75 | HRH3 (0.83) | HRH3POLBOPRM1OPRK1CXCR4 | |
| SCHEMBL10953965 | 0.74 | HRH3 (0.88) | HRH3POLBCXCR4HDAC1MEN1 | |
| SCHEMBL8808822 | 0.74 | HRH3 (0.64) | HRH3POLBCXCR4PARP1HDAC1 | |
| SCHEMBL8811299 | 0.74 | HRH3 (0.59) | HRH3POLBCXCR4PARP1HDAC1 | |
| SCHEMBL8809265 | 0.73 | SMN1; SMN2 (0.42) | CD274MEN1KMT2AALDH1A1 | |
| SCHEMBL5864236 | 0.73 | HRH3 (0.72) | HRH3POLBCXCR4HDAC1RAB9A | |
| SCHEMBL8815392 | 0.73 | HRH3 (0.62) | HRH3POLBCXCR4PARP1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784612-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-23 | — | — | EP | disclosed |