Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | RHOC | P08134 | 1/20 | 0.46 |
| ▸ | RHOA | P61586 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28965124 | 0.80 | DRD2 (0.44) | DRD2DRD4DRD3POLBACHE | |
| SCHEMBL8809145 | 0.76 | POLB (0.83) | POLBACHEOPRL1HRH3KCNH2 | |
| SCHEMBL15104644 | 0.76 | SHMT2 (0.53) | DRD2DRD4DRD3ACHEMAPT | |
| SCHEMBL5863714 | 0.74 | POLB (0.93) | POLBACHEHRH3MEN1NPC1 | |
| SCHEMBL11615671 | 0.74 | POLB (0.93) | POLBACHEHRH3MEN1NPC1 | |
| SCHEMBL28958743 | 0.74 | PDE10A (0.45) | DRD2DRD4DRD3HRH3MAPT | |
| SCHEMBL203617 | 0.73 | GFER (1.00) | GFERPOLBRHOCRHOAMAPT | |
| SCHEMBL13031632 | 0.73 | GFER (0.51) | GFERMAPTMEN1NPC1ALDH1A1 | |
| SCHEMBL11112228 | 0.72 | POLB (0.96) | POLBACHEHRH3MEN1NPC1 | |
| SCHEMBL8808533 | 0.72 | GFER (0.59) | GFERDRD2DRD4DRD3RHOC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784612-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-23 | — | — | EP | disclosed |