Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.42 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8808218 | 0.89 | ABCG2 (0.44) | MAPTMEN1KMT2AHPGDPLA2G7 | |
| SCHEMBL8808995 | 0.88 | MCHR1 (0.49) | KDRMEN1KMT2AMCHR1TP53 | |
| SCHEMBL8807862 | 0.87 | ABCG2 (0.43) | MAPTMEN1KMT2AHPGDPLA2G7 | |
| SCHEMBL8809008 | 0.82 | MAPT (0.39) | KDRMAPTMEN1KMT2AMCHR1 | |
| SCHEMBL8808214 | 0.81 | ABCG2 (0.46) | MAPTMCHR1KDM4EALDH1A1TP53 | |
| SCHEMBL8815856 | 0.80 | MEN1 (0.40) | KDRMAPTMEN1KMT2AHPGD | |
| SCHEMBL8807856 | 0.79 | ABCG2 (0.45) | MAPTMCHR1KDM4EALDH1A1TP53 | |
| SCHEMBL8807108 | 0.78 | MEN1 (0.61) | MAPTMEN1KMT2AHPGDKDM4E | |
| SCHEMBL8810132 | 0.78 | KDR (0.45) | KDRMAPTMEN1KMT2AHPGD | |
| SCHEMBL8815533 | 0.78 | KDR (0.48) | KDRMAPTMCHR1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663179-A | CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS | LABORATOIRES GLAXO SA (FR) | 1997-09-02 | — | — | US | disclosed |
| EP-0649410-B1 | ANILIDE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-02 | — | — | EP | disclosed |