Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8810943 | 0.94 | ALDH1A1 (0.40) | ERN1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL8810946 | 0.89 | TRPV4 (0.38) | ERN1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL8812701 | 0.88 | GAA (0.44) | ALDH1A1MEN1KMT2ALMNAHPGD | |
| SCHEMBL8812936 | 0.82 | ALDH1A1 (0.37) | ALDH1A1KMT2AKDM4E | |
| SCHEMBL8813933 | 0.82 | TP53 (0.39) | MEN1KMT2ALMNAHTTNPSR1 | |
| SCHEMBL8809704 | 0.82 | CTSA (0.42) | ALDH1A1MEN1KMT2ALMNAHPGD | |
| SCHEMBL8813344 | 0.81 | TDP1 (0.34) | ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL8811223 | 0.81 | TDP1 (0.45) | ALDH1A1MEN1KMT2ALMNAHPGD | |
| SCHEMBL8812863 | 0.80 | PTGER1 (0.46) | MEN1KMT2A | |
| SCHEMBL8812013 | 0.80 | TTR (0.41) | ERN1ALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997000872-A1 | 1,3,8-TRIAZA- AND 3,8-DIAZA-1-OXASPIRO(4,5)DECANE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1997-01-09 | — | — | WO | disclosed |