Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 3/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 3/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8813933 | 0.84 | TP53 (0.39) | KDM4EMAPTKMT2AMEN1LMNA | |
| SCHEMBL8812013 | 0.83 | TTR (0.41) | KDM4EALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL8809338 | 0.82 | ERN1 (0.39) | KDM4EMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL8812936 | 0.78 | ALDH1A1 (0.37) | KDM4EALDH1A1KMT2ATDP1GAA | |
| SCHEMBL8811223 | 0.77 | TDP1 (0.45) | MAPTALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL8810943 | 0.76 | ALDH1A1 (0.40) | MAPTALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL8811978 | 0.74 | GAA (0.39) | KDM4EALDH1A1TDP1L3MBTL1GAA | |
| SCHEMBL8811250 | 0.74 | ALDH1A1 (0.43) | MAPTALDH1A1KMT2AMEN1TDP1 | |
| SCHEMBL8810946 | 0.74 | TRPV4 (0.38) | ALDH1A1KMT2AMEN1HPGDLMNA | |
| SCHEMBL6273459 | 0.71 | CTSA (0.43) | CTSAKDM4EMAPTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997000872-A1 | 1,3,8-TRIAZA- AND 3,8-DIAZA-1-OXASPIRO(4,5)DECANE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1997-01-09 | — | — | WO | disclosed |